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Title   위암종에서 표피성장인자수용체의 발현과 환자의 예후와의 관계에 대한 연구 ( Prognostic Significance of Epidermal Growth Facter Receptor Experssion in Human Gastric Carcinoma )
Publicationinfo   1993 Jan; 025(01): 78-85.
Key_word   Gastric carcinoma, Epidermal growth factor, Epidermal growth factor receptor, Prognosis
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Abstract   The expression of epidermal growth factor receptor0GFR) was examined immuno- histochemically in a total of 95 gastric carcinoma, of which 71 cases(74.7%) showed immunoreactivity with either diffusely in 44 cases(46.3%) or granularly in 27 cases(28.4%). Five- year survival rates with reference to EGFR expression were as follows: 85.7% in the negatives, 69.1% in the diffuse positives and 36.0% in the grenular positives. Correlation analysis revealed that proportion of signet-ring cell(p value=0.001), Laurens classification(p value=0.008) and depth of tumor invasion(p value=0.037> were associated with the expression of EGFR. By multivariate analysis, metastasis to regional lymph nodes, EGFR expression and depth of tumor invasion were the significant prognostic factors in descending order. We concluded that EGFR expression may provide a reliable prognostic information in the gastric adenocarcinoma.
저 자   김우호(Woo Ho Kim),송상용(Sang Yong Song),최기영(Chee Young Choe),김용일(Yong Il Kim),김진복(Jin Pok Kim)